Epstein Barr virus infection in tree shrews alters the composition of gut microbiota and metabolome profile.

ABSTRACT:

Background

Epstein-Barr virus (EBV) infection is a major global threat; its manifestations range from the absence of symptoms to multiorgan malignancies and various gastrointestinal diseases. Analyzing the composition and metabolomic profile of gut microbiota during acute EBV infection might be instrumental in understanding and controlling EBV.

Methods

Six tree shrews were inoculated with EBV by intravenous injection. Blood was collected at regular intervals thereafter from the femoral vein to detect EBV and inflammatory biomarker. At the same time, tree shrew faeces were collected for 16 S rRNA gene sequencing and Non-targeted metabolomics analysis.

Results

16 S rRNA gene characterization along with β diversity analysis exhibited remarkable alterations in gut microfl

SUBMITTER: Xia W 

PROVIDER: S-EPMC10410904 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature