Itch in recessive dystrophic epidermolysis bullosa: findings of PEBLES, a prospective register study.

ABSTRACT:

Background

Itch is common and distressing in epidermolysis bullosa (EB) but has not previously been studied in depth in different recessive dystrophic EB (RDEB) subtypes.

Objectives

As part of a prospective register study of the natural history of RDEB we explored features of itch, medications used, and correlation with disease severity and quality of life.

Methods

Fifty individuals with RDEB aged 8 years and above completed the Leuven Itch Scale (LIS) (total 243 reviews over a 7-year period). Data included itch frequency, severity, duration, distress, circumstances, consequences, itch surface area and medications for itch. The iscorEB disease severity score and the validated EB quality of life tool, QOLEB, were compared to LIS domains and analysed by RDEB subtype.

SUBMITTER: Mellerio JE 

PROVIDER: S-EPMC10410928 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature