A genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry.

ABSTRACT:

Background

Genome-wide studies of gene-environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~ 7.6 million common variants and seven lifestyle/environmental risk factors for breast cancer risk overall and for estrogen receptor positive (ER +) breast cancer.

Methods

Analyses were conducted using 72,285 breast cancer cases and 80,354 controls of European ancestry from the Breast Cancer Association Consortium. Gene-environment interactions were evaluated using standard unconditional logistic regression models and likelihood ratio tests for breast cancer risk overall and for ER + breast cancer. Bayesian False Discovery Probability was employed to assess t

SUBMITTER: Middha P 

PROVIDER: S-EPMC10411002 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature