Reconstruction of the last bacterial common ancestor from 183 pangenomes reveals a versatile ancient core genome.

ABSTRACT:

Background

Cumulative sequencing efforts have yielded enough genomes to construct pangenomes for dozens of bacterial species and elucidate intraspecies gene conservation. Given the diversity of organisms for which this is achievable, similar analyses for ancestral species are feasible through the integration of pangenomics and phylogenetics, promising deeper insights into the nature of ancient life.

Results

We construct pangenomes for 183 bacterial species from 54,085 genomes and identify their core genomes using a novel statistical model to estimate genome-specific error rates and underlying gene frequencies. The core genomes are then integrated into a phylogenetic tree to reconstruct the core genome of the last bacterial common ancestor (LBCA), yielding three main results:

SUBMITTER: Hyun JC 

PROVIDER: S-EPMC10411014 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature