Causal association between major depressive disorder and coronary heart disease: a two-sample bidirectional mendelian randomization study.

ABSTRACT:

Background

Major depressive disorder (MDD) is a highly heterogeneous mental illness and a major public health problem worldwide. A large number of observational studies have demonstrated a clear association between MDD and coronary heart disease (CHD), and some studies have even suggested that the relationship is bidirectional. However, it was unknown whether any causal relationship existed between them and whether causality was bidirectional in such an instance. Thus, we aimed to determine whether there is a bidirectional causal relationship between major depressive disorders and coronary heart disease.

Methods

Our two-sample Bidirectional Mendelian Randomization Study consisted of two parts: forward MR analysis regarded MDD as exposure and CHD as the outcome, and reverse M

SUBMITTER: Xu Q 

PROVIDER: S-EPMC10411018 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature