Strain-specific changes in nucleus accumbens transcriptome and motivation for palatable food reward in mice exposed to maternal separation.

ABSTRACT:

Introduction

In humans, adversity in childhood exerts enduring effects on brain and increases the vulnerability to psychiatric diseases. It also leads to a higher risk of eating disorders and obesity. Maternal separation (MS) in mice has been used as a proxy of stress during infancy. We hypothesized that MS in mice affects motivation to obtain palatable food in adulthood and changes gene expression in reward system.

Methods

Male and female pups from C57Bl/6J and C3H/HeN mice strains were subjected to a daily MS protocol from postnatal day (PND) 2 to PND14. At adulthood, their motivation for palatable food reward was assessed in operant cages.

Results

Compared to control mice, male and female C3H/HeN mice exposed to MS increased their instrumental response for p

SUBMITTER: Benoit S 

PROVIDER: S-EPMC10411197 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature