Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression.

ABSTRACT: Lung cancer, as the most commonly diagnosed malignancy, still accounts for the leading cause of cancer-related deaths worldwide. The high rate of mortality and tumor recurrence has prompted clinicians and scientists to urgently explore new targets for improved treatment. Previous studies have indicated a potential role of the androgen receptor (AR) in the progression of non-small cell lung cancer (NSCLC). However, the precise mechanisms underlying this association, particularly its relation to TPD52-mediated cell invasion and cisplatin (DDP) response, have not been fully elucidated. Therefore, further investigation is necessary to gain a better understanding of these mechanisms and their potential implications for lung cancer treatment. In this study, we discovered that AR can suppress NSC

SUBMITTER: Liu S 

PROVIDER: S-EPMC10411467 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature