The m⁶A reader YTHDF1 attenuates fulminant hepatitis via MFG-E8 translation in an m⁶A dependent manner.

ABSTRACT: Background and Aims: N6-methyladenosine (m⁶A) is the most common post-transcriptional modification of RNA in eukaryotes, which has been demonstrated to play important roles in various biological processes. However, its roles in fulminant hepatitis remain largely unknown. In the current study, YTHDF1 expression was found to be significantly downregulated in the livers among patients, as well as murine models with fulminant hepatitis versus normal controls. Thus, we hypothesized that YTHDF1 protects against fulminant hepatitis and investigated the underlying molecular mechanisms. Methods: Fulminant hepatitis was induced by D-GalN/LPS in conventional YTHDF1 knockout (YTHDF1^-/-) mice, hepatocyte-specific YTHDF1 overexpression (AAV8- YTHDF1) mice, and corresp

SUBMITTER: Ke MY 

PROVIDER: S-EPMC10411475 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature