The effects of inversion polymorphisms on patterns of neutral genetic diversity.

ABSTRACT: The strong reduction in the frequency of recombination in heterozygotes for an inversion and a standard gene arrangement causes the arrangements to become partially isolated genetically, resulting in sequence divergence between them and changes in the levels of neutral variability at nucleotide sites within each arrangement class. Previous theoretical studies on the effects of inversions on neutral variability have assumed either that the population is panmictic or that it is divided into 2 populations subject to divergent selection. Here, the theory is extended to a model of an arbitrary number of demes connected by migration, using a finite island model with the inversion present at the same frequency in all demes. Recursion relations for mean pairwise coalescent times are used to obtain

SUBMITTER: Charlesworth B 

PROVIDER: S-EPMC10411593 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature