Longitudinal Associations between Ambient Air Pollution and Angiogenic Biomarkers among Pregnant Women in the LIFECODES Study, 2006-2008.

ABSTRACT:

Background

Exposures to ambient air pollution during pregnancy have been linked to adverse pregnancy outcomes such as preeclampsia and fetal growth restriction. Although evidence has shown that women with preeclampsia have higher ratio of soluble fms-like tyrosine kinase 1 to placental growth factor (sFlt-1/PlGF ratio), the potential impact of air pollution on markers of placental growth and function has not been well studied.

Objectives

We aimed to examine longitudinal associations between ambient air pollution exposure and angiogenic factors among pregnant women in LIFECODES, a prospective birth cohort and biorepository in Massachusetts in the United States.

Methods

PlGF and sFlt-1 were measured among pregnant women using plasma samples collected around 10, 18, 26,

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC10411633 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature