Metabolite and Lipid Biomarkers Associated With Intraocular Pressure and Inner Retinal Morphology: 1H NMR Spectroscopy Results From the UK Biobank.

ABSTRACT:

Purpose

The purpose of this study was to assess metabolites associated with intraocular pressure (IOP) and inner retina structure.

Methods

We cross-sectionally assessed 168 non-fasting plasma metabolites measured by nuclear magnetic resonance (NMR) spectroscopy with IOP (n = 28,195), macular retinal nerve fiber layer thickness (mRNFL; n = 10,584), and macular ganglion cell inner plexiform layer thickness (mGCIPL; n = 10,554) in the UK Biobank. We used multiple linear regression models adjusting for various covariates with probit-transformed metabolite levels as predictors for each outcome. Each estimate represents the difference in outcome variable per standard deviation increase in the probit-transformed metabolite values. We used the number of effective (NEF) tests and fal

SUBMITTER: Pasquale LR 

PROVIDER: S-EPMC10411643 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature