Unraveling tumor specific neoantigen immunogenicity prediction: a comprehensive analysis.

ABSTRACT:

Introduction

Identification of tumor specific neoantigen (TSN) immunogenicity is crucial to develop peptide/mRNA based anti-tumoral vaccines and/or adoptive T-cell immunotherapies; thus, accurate in-silico classification/prioritization proves critical for cost-effective clinical applications. Several methods were proposed as TSNs immunogenicity predictors; however, comprehensive performance comparison is still lacking due to the absence of well documented and adequate TSN databases.

Methods

Here, by developing a new curated database having 199 TSNs with experimentally-validated MHC-I presentation and positive/negative immune response (ITSNdb), sixteen metrics were evaluated as immunogenicity predictors. In addition, by using a dataset emulating patient derived TSNs and immun

SUBMITTER: Nibeyro G 

PROVIDER: S-EPMC10411733 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature