Implications of differential size-scaling of cell-cycle regulators on cell size homeostasis.

ABSTRACT: Accurate timing of division and size homeostasis is crucial for cells. A potential mechanism for cells to decide the timing of division is the differential scaling of regulatory protein copy numbers with cell size. However, it remains unclear whether such a mechanism can lead to robust growth and division, and how the scaling behaviors of regulatory proteins influence the cell size distribution. Here we study a mathematical model combining gene expression and cell growth, in which the cell-cycle activators scale superlinearly with cell size while the inhibitors scale sublinearly. The cell divides once the ratio of their concentrations reaches a threshold value. We find that the cell can robustly grow and divide within a finite range of the threshold value with the cell size proportional to

SUBMITTER: Ji X 

PROVIDER: S-EPMC10411824 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature