Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons.

ABSTRACT: Understanding the function of glutamate transporters has broad implications for explaining how neurons integrate information and relay it through complex neuronal circuits. Most of what is currently known about glutamate transporters, specifically their ability to maintain glutamate homeostasis and limit glutamate diffusion away from the synaptic cleft, is based on studies of glial glutamate transporters. By contrast, little is known about the functional implications of neuronal glutamate transporters. The neuronal glutamate transporter EAAC1 is widely expressed throughout the brain, particularly in the striatum, the primary input nucleus of the basal ganglia, a region implicated with movement execution and reward. Here, we show that EAAC1 limits synaptic excitation onto a po

SUBMITTER: Petroccione MA 

PROVIDER: S-EPMC10411972 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature