QuickBAM: a parallelized BAM file access API for high-throughput sequence analysis informatics.

ABSTRACT:

Motivation

In time-critical clinical settings, such as precision medicine, genomic data needs to be processed as fast as possible to arrive at data-informed treatment decisions in a timely fashion. While sequencing throughput has dramatically increased over the past decade, bioinformatics analysis throughput has not been able to keep up with the pace of computer hardware improvement, and consequently has now turned into the primary bottleneck. Modern computer hardware today is capable of much higher performance than current genomic informatics algorithms can typically utilize, therefore presenting opportunities for significant improvement of performance. Accessing the raw sequencing data from BAM files, e.g. is a necessary and time-consuming step in nearly all sequence analysis too

SUBMITTER: Pitman A 

PROVIDER: S-EPMC10412403 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature