Pneumosepsis survival in the setting of obesity leads to persistent steatohepatitis and metabolic dysfunction.

ABSTRACT:

Background

As critical care practice evolves, the sepsis survivor population continues to expand, often with lingering inflammation in many organs, including the liver. Given the concurrently increasing population of patients with NAFLD, in this study, we aimed to understand the long-term effect of sepsis on pre-existing NAFLD and hyperglycemia.

Methods

Male mice were randomized to a high-fat diet or a control diet (CD). After 24 weeks on diet, mice were inoculated with Klebsiella pneumoniae (Kpa). Serial glucose tolerance tests, and insulin and pyruvate challenge tests were performed 1 week before infection and at 2 and 6 weeks after infection. Whole tissue RNA sequencing and histological evaluation of the liver were performed. To test whether persistent inflammation could

SUBMITTER: Kumar AJ 

PROVIDER: S-EPMC10412436 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature