A cell-type-specific error-correction signal in the posterior parietal cortex.

ABSTRACT: Neurons in the posterior parietal cortex contribute to the execution of goal-directed navigation¹ and other decision-making tasks^2-4. Although molecular studies have catalogued more than 50 cortical cell types⁵, it remains unclear what distinct functions they have in this area. Here we identified a molecularly defined subset of somatostatin (Sst) inhibitory neurons that, in the mouse posterior parietal cortex, carry a cell-type-specific error-correction signal for navigation. We obtained repeatable experimental access to these cells using an adeno-associated virus in which gene expression is driven by an enhancer that functions specifically in a subset of Sst cells⁶. We found that during goal-directed navigation in a virtual environment, this sub

SUBMITTER: Green J 

PROVIDER: S-EPMC10412446 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature