CGAS-STING drives ageing-related inflammation and neurodegeneration.

ABSTRACT: Low-grade inflammation is a hallmark of old age and a central driver of ageing-associated impairment and disease¹. Multiple factors can contribute to ageing-associated inflammation²; however, the molecular pathways that transduce aberrant inflammatory signalling and their impact in natural ageing remain unclear. Here we show that the cGAS-STING signalling pathway, which mediates immune sensing of DNA³, is a critical driver of chronic inflammation and functional decline during ageing. Blockade of STING suppresses the inflammatory phenotypes of senescent human cells and tissues, attenuates ageing-related inflammation in multiple peripheral organs and the brain in mice, and leads to an improvement in tissue function. Focusing on the ageing brain, we reveal tha

SUBMITTER: Gulen MF 

PROVIDER: S-EPMC10412454 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature