Growth differentiation factor 15 predicts cardiovascular events in stable coronary artery disease

ABSTRACT:

BACKGROUND

Growth differentiation factor 15 (GDF-15) has been explored as a potential biomarker for various inflammatory diseases and cardiovascular events. This study aimed to assess the predictive role of GDF-15 levels in cardiovascular events and all-cause mortality, considering traditional risk factors and other biomarkers.

METHODS

A prospective study was conducted and 3699 patients with stable coronary artery disease (CAD) were enrolled into the research. Baseline GDF-15 levels were measured. Median follow-up was 3.1 years during the study. We analyzed clinical variables and several biomarkers. Multivariable Cox regression analysis was performed to evaluate prognostic performance of GDF-15 levels in predicting myocardial infarction (MI), heart failure, stroke, cardi

SUBMITTER: WANG J 

PROVIDER: S-EPMC10412535 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature