Convalescent plasma and all-cause mortality of COVID-19 patients: systematic review and meta-analysis.

ABSTRACT: Insight into the clinical potential of convalescent plasma in patients with coronavirus disease (COVID-19) is important given the severe clinical courses in unvaccinated and seronegative individuals. The aim of the study was to investigate whether there is a survival benefit of convalescent plasma therapy in COVID-19 patients. The authors independently assessed randomized controlled trials (RCTs) identified by the search strategy for inclusion, extracted data, and assessed risk of bias. The binary primary outcome was all-cause mortality. Risk ratio (RR) of the convalescent plasma treatment (vs. best standard care) and its associated standard error (effect size) were calculated. A random-effects model was employed to statistically pool the effect sizes of the selected studies. We included 1

SUBMITTER: Mihalek N 

PROVIDER: S-EPMC10412555 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature