Effects of COVID-19 vaccination and previous infection on Omicron SARS-CoV-2 infection and relation with serology.

ABSTRACT: An increasing proportion of the population has acquired immunity through COVID-19 vaccination and previous SARS-CoV-2 infection, i.e., hybrid immunity, possibly affecting the risk of new infection. We aim to estimate the protective effect of previous infections and vaccinations on SARS-CoV-2 Omicron infection, using data from 43,257 adult participants in a prospective community-based cohort study in the Netherlands, collected between 10 January 2022 and 1 September 2022. Our results show that, for participants with 2, 3 or 4 prior immunizing events (vaccination or previous infection), hybrid immunity is more protective against infection with SARS-CoV-2 Omicron than vaccine-induced immunity, up to at least 30 weeks after the last immunizing event. Differences in risk of infection are partly

SUBMITTER: de Gier B 

PROVIDER: S-EPMC10412579 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature