PRMT1 methylation of WTAP promotes multiple myeloma tumorigenesis by activating oxidative phosphorylation via m6A modification of NDUFS6.

ABSTRACT: Epigenetic modifications play important roles during the pathogenesis of multiple myeloma (MM). Herein, we found that protein arginine methyltransferase 1 (PRMT1) was highly expressed in MM patients, which was positively correlated with MM stages. High PRMT1 expression was correlated with adverse prognosis in MM patients. We further showed that silencing PRMT1 inhibited MM proliferation and tumorigenesis in vitro and in vivo. Mechanistically, we revealed that the knockdown of PRMT1 reduced the oxidative phosphorylation (OXPHOS) of MM cells through NDUFS6 downregulation. Meanwhile, we identified that WTAP, a key component of the m⁶A methyltransferase complex, was methylated by PRMT1, and NDUFS6 was identified as a bona fide m⁶A target of WTAP. Finally, we found that th

SUBMITTER: Jia Y 

PROVIDER: S-EPMC10412649 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature