CENPA-driven STMN1 Transcription Inhibits Ferroptosis in Hepatocellular Carcinoma.

ABSTRACT:

Background and aims

The growing knowledge of ferroptosis has suggested the regulatory role of ferroptosis in hepatocellular carcinoma (HCC), but the pertinent molecular mechanisms remain unclear. Herein, this study investigated the mechanistic basis of ferroptosis-related genes (ferrGenes) in the growth of HCC.

Methods

Differentially expressed human ferrGenes and tumor-related transcription factors (TFs) were obtained from the The Cancer Genome Atlas (TCGA) dataset and the GTEx dataset. Spearman method-based correlation analysis were conducted to construct TF-ferrGene coexpression regulatory network. Key genes associated with prognosis were singled out with Lasso regression and multivariate Cox analysis to construct the prognostic risk model. Then the accuracy and independen

SUBMITTER: Liang D 

PROVIDER: S-EPMC10412702 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature