[Identification of dynamic co-expression networks in peripheral blood of rats after middle cerebral artery occlusion].

ABSTRACT:

Objective

To identify the time dependent profiles of gene expression and featured co-expression network modules in peripheral blood of rats after middle cerebral artery occlusion (MCAO).

Methods

Microarray GSE119121 from GEO database was analyzed by R language to identify the significantly changed genes in peripheral blood at different time points (0, 1, 2, 3, 6 and 24 h) after MCAO. Gene expression patterns at different time courses were screened by STEM tools. Then, function annotation and pathway enrichment of differentially expressed genes (DEGs) were performed using the Gene Ontology (GO) database and the Kyoto Gene and Genomic Encyclopedia (KEGG) database. Depending on CEMiTool package, gene expression profile matrix was inputted into R to construct the co-expression n

SUBMITTER: Pan Z 

PROVIDER: S-EPMC10412954 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature