Hematoma-like dynamic hydrogelation through natural glycopeptide molecular recognition for infected bone fracture repair.

ABSTRACT: Infected bone fractures remain a major clinical challenge for orthopedic surgeons. From a tissue regeneration perspective, biomaterial scaffolds with antibacterial and osteoinductive activities are highly desired, while advanced materials capable of mimicking the pathological microenvironment during the healing process of infected tissues remain an area deserving more research. Hematoma, the gel-like blood coagulum, plays an essential role in bone fracture repair because of its ability to serve as a dynamic and temporary scaffold with cytokines for both pathogen elimination and tissue healing. In light of this, we designed a dynamic hydrogel with hematoma-like antimicrobial or reparative performance for infected bone fracture repair in this study. The proposed dynamic hydrogel network was

SUBMITTER: Wang S 

PROVIDER: S-EPMC10413008 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature