Identification of vaccine candidates against rhodococcus equi by combining pangenome analysis with a reverse vaccinology approach.

ABSTRACT: Rhodococcus equi (R. equi) is a zoonotic opportunistic pathogen that can cause life-threatening infections. The rapid evolution of multidrug-resistant R. equi and the fact that there is no currently licensed effective vaccine against R. equi warrant the need for vaccine development. Reverse vaccinology (RV), which involves screening a pathogen's entire genome and proteome using various web-based prediction tools, is considered one of the most effective approaches for identifying vaccine candidates. Here, we performed a pangenome analysis to determine the core proteins of R. equi. We then used the RV approach to examine the subcellular localization, host and gut flora homology, antigenicity, transmembrane helices, physicochemical properties, and immunogeni

SUBMITTER: Liu L 

PROVIDER: S-EPMC10413060 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature