Combining inflammatory miRNA molecules as diagnostic biomarkers for depression: a clinical study.

ABSTRACT:

Background

Inflammation has been implicated in core features of depression pathophysiology and treatment resistance. Therefore, new challenges in the discovery of inflammatory mediators implicated in depression have emerged. MicroRNAs (miRNAs) have been found aberrantly expressed in several pathologies, increasing their potential as biomarkers and therapeutical targets. In this study, the aim was to assess the changes and biomarker potential of inflammation-related miRNAs in depression patients.

Methods

Depression diagnosis was performed according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5). 40 healthy controls and 32 depression patients were included in the study. The levels of inflammatory cytokines were measured in plasma, and expre

SUBMITTER: Bras JP 

PROVIDER: S-EPMC10413105 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature