Building an optimal predictive model for imputing tissue-specific gene expression by combining genotype and whole-blood transcriptome data.

ABSTRACT: Accurate imputation of tissue-specific gene expression can be a powerful tool for understanding the biological mechanisms underlying human complex traits. Existing imputation methods can be grouped into two categories according to the types of predictors used. The first category uses genotype data, while the second category uses whole-blood expression data. Both data types can be easily collected from blood, avoiding invasive tissue biopsies. In this study, we attempted to build an optimal predictive model for imputing tissue-specific gene expression by combining the genotype and whole-blood expression data. We first evaluated the imputation performance of each standalone model (using genotype data [GEN model] and using whole-blood expression data [WBE model]) using their respective data t

SUBMITTER: Jung S 

PROVIDER: S-EPMC10413136 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature