Different Gabapentin and Pregabalin Dosages for Perioperative Pain Control in Patients Undergoing Spine Surgery: A Systematic Review and Network Meta-Analysis.

ABSTRACT:

Importance

Patients undergoing spine surgery often experience severe pain. The optimal dosage of pregabalin and gabapentin for pain control and safety in these patients has not been well established.

Objective

To evaluate the associations of pain, opioid consumption, and adverse events with different dosages of pregabalin and gabapentin in patients undergoing spine surgery.

Data sources

PubMed/MEDLINE, Embase, Web of Science, Cochrane library, and Scopus databases were searched for articles until August 7, 2021.

Study selection

Randomized clinical trials conducted among patients who received pregabalin or gabapentin while undergoing spine surgery were included.

Data extraction and synthesis

Two investigators independently performed data extraction follow

SUBMITTER: Tsai SHL 

PROVIDER: S-EPMC10413173 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature