Developmental delay in infants and toddlers with sickle cell disease: a systematic review.

ABSTRACT:

Aim

To summarize developmental delay among infants and toddlers with sickle cell disease (SCD).

Method

This systematic review included studies that reported developmental outcomes of children with SCD between 0 months and 48 months of age and followed standards set forth by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.

Results

Ten studies were included, describing 596 unique developmental assessments. The rate of developmental delay ranged from 17.5% to 50% and increased with age. Cognition was the only domain included in all studies and the most frequently identified delay. One study reported that more severe SCD genotypes predicted worse development, while five studies reported no difference in rates of developmental del

SUBMITTER: Hoyt CR 

PROVIDER: S-EPMC10413179 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature