Association of Genetically Predicted Insomnia With Risk of Sepsis: A Mendelian Randomization Study.

ABSTRACT:

Importance

Insomnia has been associated with altered inflammatory response as well as increased risk of infections and sepsis in observational studies. However, these studies are prone to bias, such as residual confounding. To further understand the potential causal association between insomnia and sepsis risk, a 2-sample Mendelian randomization (MR) approach should be explored.

Objective

To evaluate whether genetically predicted insomnia is associated with risk of sepsis.

Design, setting, and participants

Two-sample MR was performed to estimate the association between genetically predicted insomnia and sepsis risk. Data were obtained from a genome-wide association study identifying 555 independent genetic variants (R2 < 0.01) strongly associated with insomnia (P < 5 

SUBMITTER: Thorkildsen MS 

PROVIDER: S-EPMC10413214 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature