Potential of GC-Combustion-MS as a Powerful and Versatile Nitrogen-Selective Detector in Gas Chromatography.

ABSTRACT: Here, we show the potential and applicability of the novel GC-combustion-MS approach as a nitrogen-selective GC detector. Operating requirements to achieve reproducible and compound-independent formation of volatile NO species as a selective N-signal during the combustion step are described. Specifically, high temperatures (≥1000 °C) and post-column O₂ flows (0.4 mL min^-1 of 0.3% O₂ in He) turned out to be necessary when using a vertical oven without makeup flow (prototype #1). In contrast, the use of a horizontal oven with 1.7 mL min^-1 He as an additional makeup flow (prototype #2) required milder conditions (850 °C and 0.2 mL min^-1). A detection limit of 0.02 pg of N injected was achieved, which is by far the lowest ever reported for

SUBMITTER: Garcia-Bellido J 

PROVIDER: S-EPMC10413323 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature