Developmental Pb exposure increases AD risk via altered intracellular Ca²⁺ homeostasis in hiPSC-derived cortical neurons.

ABSTRACT: Exposure to environmental chemicals such as lead (Pb) during vulnerable developmental periods can result in adverse health outcomes later in life. Human cohort studies have demonstrated associations between developmental Pb exposure and Alzheimer's disease (AD) onset in later life which were further corroborated by findings from animal studies. The molecular pathway linking developmental Pb exposure and increased AD risk, however, remains elusive. In this work, we used human iPSC-derived cortical neurons as a model system to study the effects of Pb exposure on AD-like pathogenesis in human cortical neurons. We exposed neural progenitor cells derived from human iPSC to 0, 15, and 50 ppb Pb for 48 h, removed Pb-containing medium, and further differentiated them into cortical neurons. Immunof

SUBMITTER: Xie J 

PROVIDER: S-EPMC10413359 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature