Blood pressure and vascular determinants of glomerular filtration rate decline in diabetic kidney disease.

ABSTRACT:

Objective

In patients with type 2 diabetes and diabetic kidney disease (DKD), explore the relationship between estimated glomerular filtration rate decline (eGFR-d) and simultaneously assessed vascular risk markers including office, ambulatory or central blood pressure, pulse pressure, carotid-femoral pulse wave velocity (PWV), carotid intima-media thickness (IMT) and renal resistive indexes (RRI).

Research design and methods

At baseline, vascular risk markers were measured in addition to the routine clinical workup. The eGFR-d was based on 2000-2019 creatinine values. Parameters were compared by eGFR-d quartiles. Regression models of eGFR-d and vascular markers were assessed.

Results

In total, 135 patients were included. Mean age was 63.8 ± 10.8y, baseline eGFR 60.2 

SUBMITTER: Truscello L 

PROVIDER: S-EPMC10413385 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature