Roles of DNA Target in Cancer Cell-Selective Cytotoxicity by Dicopper Complexes with DNA Target/Ligand Conjugates.

ABSTRACT: The DNA target/ligand conjugates (HL^X, X = Pn and Mn, n = 1-3) were synthesized where various lengths of -CONH(CH₂CH₂O)_nCH₂CH₂NHCO- linkers with a 9-phenanthrenyl (P) or methyl (M) terminal as DNA targets replace the methyl group of 2,6-di(amide-tether cyclen)-p-cresol ligand (HL). DNA binding, DNA cleavage, cellular uptake, and cytotoxicity of [Cu₂(μ-OH)(L^X)](ClO₄)₂ (1^X) are examined and compared with those of [Cu₂(μ-OH)(L)](ClO₄)₂ (1) to clarify roles of DNA targets. Upon reaction of 1^X with H₂O₂, μ-1,1-O₂H complexes are formed for DNA cl

SUBMITTER: Hata M 

PROVIDER: S-EPMC10413468 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature