Extended genetic analysis and tumor characteristics in over 4600 women with suspected hereditary breast and ovarian cancer.

ABSTRACT:

Background

Genetic screening for pathogenic variants (PVs) in cancer predisposition genes can affect treatment strategies, risk prediction and preventive measures for patients and families. For decades, hereditary breast and ovarian cancer (HBOC) has been attributed to PVs in the genes BRCA1 and BRCA2, and more recently other rare alleles have been firmly established as associated with a high or moderate increased risk of developing breast and/or ovarian cancer. Here, we assess the genetic variation and tumor characteristics in a large cohort of women with suspected HBOC in a clinical oncogenetic setting.

Methods

Women with suspected HBOC referred from all oncogenetic clinics in Sweden over a six-year inclusion period were screened for PVs in 13 clinically relevant genes. Th

SUBMITTER: Ofverholm A 

PROVIDER: S-EPMC10413543 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature