TMEM106B aggregation in neurodegenerative diseases: linking genetics to function.

ABSTRACT:

Background

Mutations of the gene TMEM106B are risk factors for diverse neurodegenerative diseases. Previous understanding of the underlying mechanism focused on the impairment of lysosome biogenesis caused by TMEM106B loss-of-function. However, mutations in TMEM106B increase its expression level, thus the molecular process linking these mutations to the apparent disruption in TMEM106B function remains mysterious.

Main body

Recent new studies reported that TMEM106B proteins form intracellular amyloid filaments which universally exist in various neurodegenerative diseases, sometimes being the dominant form of protein aggregation. In light of these new findings, in this review we systematically examined previous efforts in understanding the function of TMEM106B in physiological

SUBMITTER: Jiao HS 

PROVIDER: S-EPMC10413548 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature