Integrating bioinformatic resources to identify characteristics of rheumatoid arthritis-related usual interstitial pneumonia.

ABSTRACT:

Background

Rheumatoid arthritis (RA) is often accompanied by a common extra-articular manifestation known as RA-related usual interstitial pneumonia (RA-UIP), which is associated with a poor prognosis. However, the mechanism remains unclear. To identify potential mechanisms, we conducted bioinformatics analysis based on high-throughput sequencing of the Gene Expression Omnibus (GEO) database.

Results

Weighted gene co-expression network analysis (WGCNA) analysis identified 2 RA-positive related modules and 4 idiopathic pulmonary fibrosis (IPF)-positive related modules. A total of 553 overlapped differentially expressed genes (DEG) were obtained, of which 144 in the above modules were further analyzed. The biological process of "oxidative phosphorylation" was found to be the m

SUBMITTER: Qiu Y 

PROVIDER: S-EPMC10413595 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature