Disentangling the link between zebrafish diet, gut microbiome succession, and Mycobacterium chelonae infection.

ABSTRACT:

Background

Despite the long-established importance of zebrafish (Danio rerio) as a model organism and their increasing use in microbiome-targeted studies, relatively little is known about how husbandry practices involving diet impact the zebrafish gut microbiome. Given the microbiome's important role in mediating host physiology and the potential for diet to drive variation in microbiome composition, we sought to clarify how three different dietary formulations that are commonly used in zebrafish facilities impact the gut microbiome. We compared the composition of gut microbiomes in approximately 60 AB line adult (129- and 214-day-old) zebrafish fed each diet throughout their lifespan.

Results

Our analysis finds that diet has a substantial impact on the composition of the gu

SUBMITTER: Sieler MJ 

PROVIDER: S-EPMC10413624 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature