Fear extinction relies on ventral hippocampal safety codes shaped by the amygdala.

ABSTRACT: Extinction memory retrieval is influenced by spatial contextual information that determines responding to conditioned stimuli (CS). However, it is poorly understood whether contextual representations are imbued with emotional values to support memory selection. Here, we performed activity-dependent engram tagging and in vivo single-unit electrophysiological recordings from the ventral hippocampus (vH) while optogenetically manipulating basolateral amygdala (BLA) inputs during the formation of cued fear extinction memory. During fear extinction when CS acquire safety properties, we found that CS-related activity in the vH reactivated during sleep consolidation and was strengthened upon memory retrieval. Moreover, fear extinction memory was facilitated when the extinction context exhibited p

SUBMITTER: Nguyen R 

PROVIDER: S-EPMC10413664 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature