Multifaceted role of redox pattern in the tumor immune microenvironment regarding autophagy and apoptosis.

ABSTRACT: The reversible oxidation-reduction homeostasis mechanism functions as a specific signal transduction system, eliciting related physiological responses. Disruptions to redox homeostasis can have negative consequences, including the potential for cancer development and progression, which are closely linked to a series of redox processes, such as adjustment of reactive oxygen species (ROS) levels and species, changes in antioxidant capacity, and differential effects of ROS on downstream cell fate and immune capacity. The tumor microenvironment (TME) exhibits a complex interplay between immunity and regulatory cell death, especially autophagy and apoptosis, which is crucially regulated by ROS. The present study aims to investigate the mechanism by which multi-source ROS affects apoptosis, auto

SUBMITTER: Ren Y 

PROVIDER: S-EPMC10413697 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature