Subthalamic 85 Hz deep brain stimulation improves walking pace and stride length in Parkinson's disease patients.

ABSTRACT:

Background

Mobile gait sensors represent a compelling tool to objectify the severity of symptoms in patients with idiopathic Parkinson's disease (iPD), but also to determine the therapeutic benefit of interventions. In particular, parameters of Deep Brain stimulation (DBS) with its short latency could be accurately assessed using sensor data. This study aimed at gaining insight into gait changes due to different DBS parameters in patients with subthalamic nucleus (STN) DBS.

Methods

An analysis of various gait examinations was performed on 23 of the initially enrolled 27 iPD patients with chronic STN DBS. Stimulation settings were previously adjusted for either amplitude, frequency, or pulse width in a randomised order. A linear mixed effects model was used to analyse changes

SUBMITTER: Mugge F 

PROVIDER: S-EPMC10413698 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature