Modeling of factors affecting late gadolinium enhancement kinetics in MRI of cardiac amyloid.

ABSTRACT:

Background

Late gadolinium enhancement (LGE) is a valuable part of cardiac magnetic resonance imaging (CMR). In particular, inversion-recovery imaging of LGE, with nulling of the signal from reference areas of myocardium, can have a distinctive pattern in some patients with cardiac amyloid, including both diffuse (relatively faint) subendocardial LGE and a relatively dark appearance of the blood. However, the underlying reasons for this distinctive appearance have not previously been well investigated. Pharmacokinetic modeling of myocardial contrast enhancement kinetics can potentially provide insight into the mechanisms of the distinctive LGE appearance that can be seen in cardiac amyloid, as well as why it may be unreliable in some patients.

Methods

An interactive three-co

SUBMITTER: Axel L 

PROVIDER: S-EPMC10413700 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature