Enhancing involvement of people with multiple sclerosis in clinical trial design.

ABSTRACT:

Background

Although often overlooked, patient and public involvement (PPI) is vital when considering the design and delivery of complex and adaptive clinical trial designs for chronic health conditions such as multiple sclerosis (MS).

Methods

We conducted a rapid review to assess current status of PPI in the design and conduct of clinical trials in MS over the last 5 years. We provide a case study describing PPI in the development of a platform clinical trial in progressive MS.

Results

We identified only eight unique clinical trials that described PPI as part of articles or protocols; nearly, all were linked with funders who encourage or mandate PPI in health research. The OCTOPUS trial was co-designed with people affected by MS. They were central to every aspect from

SUBMITTER: Gray E 

PROVIDER: S-EPMC10413782 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature