Unveiling the Rational Development of Stimuli-Responsive Silk Fibroin-Based Ionogel Formulations.

ABSTRACT: We present an approach for the rational development of stimuli-responsive ionogels which can be formulated for precise control of multiple unique ionogel features and fill niche pharmaceutical applications. Ionogels are captivating materials, exhibiting self-healing characteristics, tunable mechanical and structural properties, high thermal stability, and electroconductivity. However, the majority of ionogels developed require complex chemistry, exhibit high viscosity, poor biocompatibility, and low biodegradability. In our work, we overcome these limitations. We employ a facile production process and strategically integrate silk fibroin, the biocompatible ionic liquids (ILs) choline acetate ([Cho][OAc]), choline dihydrogen phosphate ([Cho][DHP]), and choline chloride ([Cho][Cl]), traditio

SUBMITTER: Shmool TA 

PROVIDER: S-EPMC10413859 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature