Novel applications of histopathological markers to distinguish prognostic subgroups in colorectal adenocarcinoma.

ABSTRACT:

Objective

To explore the novel applications of histological factors by stratifying the prognostic markers of the overall CRC patients in subgroups.

Materials and methods

A total of 17 histopathological and molecular factors were retrospectively collected and systematically analyzed for the prediction of CRC prognosis in the overall and stratified subgroups by using the Kaplan-Meier curve analysis as well as the Cox regression test. The χ² test was used to analyze the correlation of the prognostic markers with other factors.

Results

The histopathological markers including the lymph node metastasis (LNM), perineural/venous invasion (PVI), TNM stage, the local recurrence or distant metastasis after surgery (R/M) and the molecular markers Ki-67 expression as we

SUBMITTER: Yuan Y 

PROVIDER: S-EPMC10413918 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature