Cup is essential for oskar mRNA translational repression during early Drosophila oogenesis.

ABSTRACT: Study of the timing and location for mRNA translation across model systems has begun to shed light on molecular events fundamental to such processes as intercellular communication, morphogenesis, and body pattern formation. In D. melanogaster, the posterior mRNA determinant, oskar, is transcribed maternally but translated only when properly localized at the oocyte's posterior cortex. Two effector proteins, Bruno1 and Cup, mediate steps of oskar mRNA regulation. The current model in the field identifies Bruno1 as necessary for Cup's recruitment to oskar mRNA and indispensable for oskar's translational repression. We now report that this Bruno1-Cup interaction leads to precise oskar mRNA regulation during early oogenesis and, importantly, the two pro

SUBMITTER: Bayer LV 

PROVIDER: S-EPMC10413924 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature