Kinetic models for estimating occupancy from single-scan PET displacement studies.

ABSTRACT: The traditional design of PET target engagement studies is based on a baseline scan and one or more scans after drug administration. We here evaluate an alternative design in which the drug is administered during an on-going scan (i.e., a displacement study). This approach results both in lower radiation exposure and lower costs. Existing kinetic models assume steady state. This condition is not present during a drug displacement and consequently, our aim here was to develop kinetic models for analysing PET displacement data. We modified existing compartment models to accommodate a time-variant increase in occupancy following the pharmacological in-scan intervention. Since this implies the use of differential equations that cannot be solved analytically, we developed instead one approximat

SUBMITTER: Laurell GL 

PROVIDER: S-EPMC10414003 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature