Long-term comparative effectiveness of antihypertensive monotherapies in primary prevention of cardiovascular events: a population-based retrospective inception cohort study in the Netherlands.

ABSTRACT:

Objective

To determine the long-term effectiveness of antihypertensive monotherapies in primary prevention of cardiovascular events.

Design

Retrospective inception cohort study covering a 25-year study period.

Setting

University Groningen IADB.nl pharmacy prescription database with data from 1996 to 2020.

Participants

Patients aged 18 years or older, free of any cardiovascular disease (CVD) drug therapies prior to initiation of a preventive antihypertensive monotherapy (ACE inhibitors (ACEIs), angiotensin II receptor blockers (ARBs), beta-blockers (BBs), calcium channel blockers (CCBs) and thiazides).

Outcome measures

Primary outcome was the time to first prescription of acute cardiac drug therapy (CDT) measured by valid drug proxies to identify a first

SUBMITTER: Li X 

PROVIDER: S-EPMC10414115 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature