Functional tumor cell-intrinsic STING, not host STING, drives local and systemic antitumor immunity and therapy efficacy following cryoablation.

ABSTRACT:

Background

Despite its potential utility in delivering direct tumor killing and in situ whole-cell tumor vaccination, tumor cryoablation produces highly variable and unpredictable clinical response, limiting its clinical utility. The mechanism(s) driving cryoablation-induced local antitumor immunity and the associated abscopal effect is not well understood.

Methods

The aim of this study was to identify and explore a mechanism of action by which cryoablation enhances the therapeutic efficacy in metastatic tumor models. We used the subcutaneous mouse model of the rhabdomyosarcoma (RMS) cell lines RMS 76-9^STINGwt or RMS 76-9^STING-/-, along with other murine tumor models, in C57BL/6 or STING^-/- (TMEM173^-/- ) mice to evaluate loc

SUBMITTER: Alshebremi M 

PROVIDER: S-EPMC10414127 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature